Defending champion Naomi Osaka and Russian fifth seed Andrey Rublev will play feature matches at Arthur Ashe Stadium on Friday night.
Four-time Grand Slam winner Osaka, the third seed from Japan, will meet Canada’s 73rd seeded Leylah Fernandez in the night opener.
Osaka is looking to become the first back-to-back US Open women’s champion since Serena Williams captured her third in a row in 2014. She is also aiming for her third US Open crown in four years.
Rublev, never better than in the last eight in a Slam, takes on American Frances Tiafoe in the closer. Rublev has reached two of his four Slam quarterfinals in New York.
Two-time Grand Slam champions Garbine Muguruza, the ninth seed from Spain, and Victoria Azarenka, the eighteenth seed from Belarus, meet in the day opener at Ashe. Azarenka finished second at the US Open for the third time last year.
Greek third seed Stefanos Tsitsipas will face Spaniard Carlos Alcaraz in the second game at Ashe.
At the Louis Armstrong Stadium, two-time Grand Slam champion Simona Halep, the 12th seed from Romania, plays the first game against the 19th seed of Kazakhstan Elena Rybarkina.
The Russian second seed Daniil Medvedev follows against the Spaniard Pablo Andujar.
Germany’s 16th-seeded Angelique Kerber will face American Sloane Stephens, the 2017 US Open champion, in the third match at Armstrong, with the winner in position to face Osaka in the fourth round.
Belarus second-seeded Aryna Sabalenka will face 26th-seeded American Danielle Collins in the final night game against Armstrong.